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哺乳动物下丘脑视交叉上核（ＳＣＮ）在昼夜节律的发生和调节中起着非常重要的作用。它大量接受来自中缝背核（ＤＲ）神经元的神经支配。本实验结果表明，不论在正常光照条件下，或者在连续光照和连续黑暗条件下，损毁ＤＲ后，小鼠踏转轮运动的昼夜节律消失；注射５—ＨＴ台成抑制剂对氯苯百氨酸后，踏转轮运动的节律也消失，但在注射后第７天起开始恢复。结果提示，从ＤＲ到ＳＣＮ的５－ＨＴ能神经传递可能参与踏转轮活动的昼夜节律调节。
The mammalian hypothalamic suprachiasmatic nucleus (SCN) plays a very important role in the generation and regulation of circadian rhythms. It receives a large number of innervations from the dorsal raphe (DR) neurons. The experimental results show that circadian rhythms of treadmill movement of mice disappeared in both normal and continuous light and continuous darkness after DR was destroyed. Injection of 5-HT as inhibitor of chlorobenzene After acid, the rhythm of stepping wheel movement also disappeared, but began to recover on the 7th day after injection. The results suggest that 5-HT neurotransmission from DR to SCN may be involved in circadian rhythm regulation of treadmill activity.