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目的:观察枯草杆菌二联活菌联合美沙拉嗪对溃疡性结肠炎血清炎症因子的影响。方法:选取2015年9月至2016年4月于我院收治的溃疡性结肠炎患者88例,随机分为对照组和联合组,各44例。对照组口服美沙拉嗪进行治疗,联合组加服枯草杆菌二联活菌联合治疗。观察两组治疗效果。结果:对照组治疗有效率低于联合组,丙二醛(MDA)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)等水平高于联合组,差异有统计学意义(P<0.05)。结论:枯草杆菌二联活菌与美沙拉嗪联合治疗溃疡性结肠炎可有效改善血清炎症因子水平,提高治疗有效率。
Objective: To observe the effect of Bacillus subtilis viable combined with mesalazine on serum inflammatory cytokines in patients with ulcerative colitis. Methods: From September 2015 to April 2016, 88 patients with ulcerative colitis admitted to our hospital were randomly divided into control group and combination group, with 44 cases in each group. The control group was treated with mesalazine orally, and the combination group was given combined treatment of B. subtilis and viable bacteria. Observation of two groups treatment effect. Results: The effective rate of the control group was lower than that of the combined group. The levels of malondialdehyde (MDA), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were higher in the control group than those in the combined group (P <0.05). Conclusion: The combination of B. subtilis viable with mesalazine in the treatment of ulcerative colitis can effectively improve the level of serum inflammatory cytokines and improve the treatment efficiency.