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为了观察化瘀解毒汤对肾间质纤维化的改善作用，用ＵＵＯ诱导肾间质纤维化动物模型，予以化瘀解毒汤进行防治。结果显示各治疗组大鼠肾间质ＴＧＦβ_１ ｍＲＮＡ表达及血浆ＡｎｇⅡ浓度较模型组显著降低（Ｐ＜０．０５），尤以预防组更佳。肾脏组织病理检查也有明显改善。提示化瘀解毒汤具有抑制肾素─血管紧张素系统激活，抑制ＴＧＦβ分泌，抗肾间质纤维化的作用。
In order to observe the effect of Huayu Jiedu Decoction on renal interstitial fibrosis, an animal model of renal interstitial fibrosis induced by UUO was used to prevent and treat it. The results showed that the expression of TGFβ_1 mRNA and plasma Ang II in renal interstitial tissue of each treatment group were significantly lower than those in the model group (P<0.05), especially in the prevention group. Kidney pathological examination also showed significant improvement. It is suggested that Huatanjiedu Decoction can inhibit the activation of renin-angiotensin system, inhibit the secretion of TGFβ, and prevent renal interstitial fibrosis.