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由于各种药物的物理、化学和药理作用不同,同时使用两种或两种以上药物在机体特定环境影响下可能引起药物间的相互作用,结果可表现为药效相加、协同或互相拮抗。因此,利用药物相互作用的原理,适当地采取多种药物联合治疗,往往比单用一种药物治疗效果大,或可减轻主要药物的副作用。但是,有些药物也可产生对患者有害的相互作用,致使药效降低或消失,毒性增加,或出现严重的并发症,甚至死亡。显然,探讨药物相互作用的原理,充分利用其有利的一面,避免其不利的一面,使药物治疗达到理想的预期效果,无疑有着重要的临床意义。
Due to the different physical, chemical and pharmacological effects of various drugs, the simultaneous use of two or more drugs may cause the drug-drug interaction under the influence of the specific environment of the body. The results may be additive, synergistic or antagonistic. Therefore, taking advantage of the principle of drug interactions, appropriate combination of multiple drugs is often more effective than treatment with one drug alone, or it can reduce the side effects of the primary drug. However, some drugs can also produce harmful interactions with patients resulting in diminished or diminished efficacy, increased toxicity, or serious complications and even death. Obviously, to explore the principle of drug interactions, make full use of its positive side, to avoid its negative side, so that drug treatment to achieve the desired effect, no doubt has important clinical significance.