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未满月大鼠肝脏金属硫蛋白(MT)的浓度为成年大鼠的10～20倍,因此,未成熟大鼠是否比成年大鼠对镉(Cd)的肝毒性作用具有更大的耐受性?为此,作者选择10日龄的Sprague-Dawley大鼠进行实验。设雄性成年大鼠二组,一组静脉注射Cd的肝毒剂量4.0mgCd/kg,另一组为对照组,给予生理盐水2ml/kg。设10日龄大鼠四组,分别注射生理盐水2ml/kg及镉4.0、5.0和6.0mg/kg。为了测定Cd在两种大鼠主要器官和肝的亚细胞的分
The concentration of hepatic metallothionein (MT) in under-full-term rats is 10 to 20 times that of adult rats, so immature rats are more tolerant to the hepatotoxic effects of cadmium (Cd) in adult rats For this reason, the authors selected 10-day-old Sprague-Dawley rats for experiments. Two groups of male adult rats were set up. One group received hepatic toxic dose of 4.0 mg Cd / kg intravenously and the other group received normal saline (2 ml / kg). The 10-day-old rats were divided into four groups and injected with saline 2ml / kg and cadmium 4.0, 5.0 and 6.0mg / kg, respectively. To determine the subcellular fraction of Cd in both rat major organs and liver