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Fletcher 等于1959年首先证实采用静脉内溶栓疗法治疗急性心肌梗塞是可行的。其后至少有20个对照试验,对急性心肌梗塞病人静脉内溶栓进行了观察,主要终点是病死率,7个试验证明静脉溶栓疗法能改善急性心肌梗塞存活率(有统计学意义)。欧洲协作研究组证明,依据单纯临床标准
Fletcher et al. First confirmed in 1959 that intravenous thrombolytic therapy for acute myocardial infarction was feasible. Followed by at least 20 controlled trials of intravenous thrombolysis in patients with acute myocardial infarction were observed, the main end point is the case fatality rate, 7 trials showed that intravenous thrombolytic therapy can improve the survival rate of acute myocardial infarction (statistically significant). European collaborative research group to prove that based on purely clinical criteria