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苯妥英钠(DPH)为非线性代谢药物,因有个体差异,服药剂量与血浓度不成比例的情况不少见。进行血浓度监测有利于指导剂量的调整,提高疗效;减少毒副作用和联合用药。我科与药剂科协作自1986年开展DPH血浓度测定。现将93例服用DPH的癫痫病人的测定结果做一报告: 1 资料与方法 临床资料:本组93例,男59例,女34例,年龄2.5—27岁,平均年龄27.21岁。病程半月—30年,平均7.97年。大发作83例,局限性发作8例,持续状态及头痛型各1例。有病因可查者46例,其中有头外伤史者14例,各种脑炎及脑膜炎12例,产伤5例,脑血管病6
Phenytoin sodium (DPH) is a non-linear metabolic drug, due to individual differences, taking the dose and the blood concentration is not the case is not uncommon. Blood concentration monitoring is conducive to guide the dose adjustment, improve the efficacy; reduce side effects and combination therapy. Our department and pharmacy collaboration DPH blood concentration determination since 1986. 93 cases of epilepsy patients taking DPH do a report: 1 Materials and Methods Clinical data: The group of 93 patients, 59 males and 34 females, aged 2.5-27 years, with an average age of 27.21 years. Half a month duration - 30 years, an average of 7. 97 years. 83 cases of major episode, 8 cases of localized attack, and 1 case of persistent state and headache. There are 46 cases of etiological investigation, including 14 cases of head trauma history, a variety of encephalitis and meningitis in 12 cases, 5 cases of birth trauma, cerebrovascular disease 6