目的　188铼 ( 188Re)标记用于肿瘤靶向治疗的白蛋白磁纳米体的实验室条件。方法　　188Re标记白蛋白磁性纳米体的最佳实验室条件是 :SnCl2 ·H2 O 8mg/ml,柠檬酸 2 0mg/ml,维生素C 8mg/ml,反应容积为 5 0 0 μl ,反应时间为 3h。结果　188Re总的标记率大于 90 % ,标记稳定性 7h为 98%、2 4h为 95 %。结论　188Re-白蛋白磁性纳米体的标记率及标记稳定性适于用于肿瘤靶向治疗的体内研究。 Objective 188 (188Re) labeling laboratory conditions for albumin-targeted therapy of albumin magnetic nanobody. Methods The best laboratory conditions for labeling albumin magnetic nanoparticles with 188Re were: SnCl2 ·H2O 8 mg/ml, citric acid 20 mg/ml, vitamin C 8 mg/ml, reaction volume 500 μl, reaction time 3 h. Results The total labeling rate of 188Re was greater than 90%, and the labeling stability was 98% at 7h and 95% at 24 hours. Conclusion The labeling rate and labeling stability of 188Re-albumin magnetic nanobody are suitable for the in vivo study of tumor-targeted therapy.