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作者认为粘膜纤毛功能障碍是小儿复发性上感、中耳炎、鼻窦炎以及慢性支气管炎的病因。纤毛结构电镜观察见此综合征除纤毛内缺乏含ATP的动臂(dynein arms)外,还有许多纤毛结构的改变,如纤毛膜切面检查发现中央微管方向紊乱、放射状细丝(radial spoke)缺乏、外微管增多、纤毛粘合等。用电镜常规检查太费时间,功能性检查对小儿又不实用。作者采用了放射性同位素检查初筛。被检小儿年龄在3个月至15岁(平均年龄8岁)共46例。主症中表现为复发性上感23例,慢性支气管炎7例,复发性中耳炎23例,复发性鼻窦炎21例。用~(99m)锝血清蛋白为示踪剂,以γ照相机追踪以测量鼻粘膜纤毛运送速度,结果以mm/分记录。若一侧鼻腔示踪剂不动则立即于对
The authors believe that mucociliary dysfunction is a cause of recurrent upper respiratory infection, otitis media, sinusitis and chronic bronchitis in children. Ciliary structure observed by electron microscopy in this syndrome, in addition to lack of ciliary tract with ATP-containing dynein arms, there are many changes in the structure of the cilia, such as ciliary film section examination found that the direction of the central microtubule disorder, radial filaments (radial spoke) Lack of external microtubules, such as cilia adhesion. Using conventional electron microscopy is too time-consuming, functional tests are not practical for children. The authors used a radioisotope screening test. A total of 46 infants aged 3 months to 15 years old (mean age 8 years) were examined. Main symptoms manifested as recurrent upper flu in 23 cases, chronic bronchitis in 7 cases, 23 cases of recurrent otitis media, recurrent sinusitis in 21 cases. Tracked nasal mucosal cilia with ~ (99m) technetium serum protein as a tracer, followed by a gamma camera, and the results are reported in mm / min. If the side of the nasal tracer does not move immediately on the right