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目的:初步探讨罗伯逊易位对控制性超促排卵(COH)中卵巢反应性的影响。方法:回顾性分析12个周期针对罗伯逊易位不孕夫妇行胚胎植入前遗传学诊断(PGD)的COH方案,其中女性罗伯逊易位携带者(研究组)5个周期,男性罗伯逊易位携带者(对照组)7个周期。比较分析患者年龄、体质量指数(BMI)、基础内分泌及COH中降调节天数、Gn使用天数、Gn用量、hCG注射日E2值、获卵数、2PN受精率、2PN卵裂率、移植胚胎数等。结果:年龄、BMI、基础内分泌及COH中降调节天数、Gn使用天数、2PN受精率、2PN卵裂率、移植胚胎数及获卵数组间无统计学差异,但研究组的Gn用量(3 128.6±891.3 IU)明显高于对照组(1 810.0±630.9 IU)(P<0.05);研究组hCG注射日E2值为3 233.8±1 938.2 pg/ml,明显低于对照组的8 143.6±1 926.3 pg/ml(P<0.05)。结论:染色体罗伯逊易位影响卵巢对COH的反应性。
Objective: To investigate the effect of Robertson’s translocation on ovarian response in controlled hyperstimulation (COH). Methods: A retrospective analysis of 12 cycles of Rohosunxian infertility couple preimplantation genetic diagnosis (PGD) COH program, including female Robertson translocation carriers (study group) 5 cycles, male Robertson translocation (Control group) 7 cycles. The age, body mass index (BMI), basal endocrine and COH decreasing days, Gn use days, Gn dosage, E2 value on hCG injection day, number of oocytes retrieved, 2PN fertilization rate, 2PN cleavage rate, Wait. Results: There were no significant differences in age, BMI, basal endocrine and the number of down-regulation days, Gn use days, 2PN fertilization rate, 2PN cleavage rate, ± 891.3 IU) was significantly higher than that of the control group (1 810.0 ± 630.9 IU) (P <0.05). The E2 value of the study group on day 3 of hCG injection was 3 233.8 ± 1 938.2 pg / ml, which was significantly lower than that of the control group 8 143.6 ± 1 926.3 pg / ml (P <0.05). Conclusion: Chromosome Robertsonian translocation affects ovarian response to COH.