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近年来有关心绞痛的研究进展较大。本文仅就其中较为重要的几个问题综合文献加以叙述。前列腺素与心绞痛前列腺素(PG)与动脉硬化、心肌梗塞、心绞痛相关的研究,近年非常受到重视,并取得了可喜的成果。心脏合成PG主要合成部位是在有磷酸脂酶的冠脉血管,而非心肌。在血管壁上,由花生四烯酸径PCH_2合成为前列环素(PGl_2)。它很不稳定,具有强力血管扩张作用和血小板聚集作用。其终末产物是较稳定的6-酮-GI1α(6-Keto-PGI1α)。另一方面,当血管壁损伤时,当血管壁损伤时,血小板粘附于核处,从其致密体和α颗粒中释放出二磷酸腺苷、血清素。同时因环氧化酶
In recent years, research on angina has made great progress. This article only describes the comprehensive literature on the more important issues. Prostaglandin and angina pectoris (PG) and atherosclerosis, myocardial infarction, angina-related research, in recent years very much attention, and achieved gratifying results. The main synthetic site of cardiac synthesis of PG is in the coronary artery with phospholipase, not myocardium. In the vascular wall, synthesized by the arachidonic acid PCH_2 prostacyclin (PGl_2). It is very unstable, with strong vasodilatation and platelet aggregation. Its final product is the more stable 6-keto-GI1α (6-Keto-PGI1α). On the other hand, when the blood vessel wall is damaged, when the blood vessel wall is damaged, the platelet adheres to the nucleus to release adenosine diphosphate and serotonin from the dense body and the α particle. At the same time because of cyclooxygenase