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本文报道2例应用静注新青霉素Ⅱ治愈的葡萄球菌心内膜炎,因滥用而引起了肝脏中毒。病例1 38岁、女性、非肠道性海洛因和麻醉剂成瘾患者。因呼吸困难、咳嗽、发热、寒战、恶心、呕吐4天而入院。否认以前有黄疸或肝炎史,亦否认过敏、接触肝毒素或输血史。体温103°F。左肺肺底有罗音。白细胞计数17,000/mm~3,中性90%,血沉(长管法)70mm/小时。尿检查白细胞25/高倍镜象。痰查见固紫染色阳性球菌,胸片左肺下叶浸润。入院当天,按肺炎和细菌性心内膜炎治疗,每天静注新青霉毒Ⅱ16g。以后数天,痰及6次血培养为金黄色葡萄球菌阳性。当时SGOT为15IU(正常5～40)。住院第23天,升至420IU。住院第28天,当施行经皮肝活检时停止新青Ⅱ治疗。开始氯林肯霉素治疗时,SGOT和SGPT继续升高,分别为1380和1164IU,
This article reports 2 cases of intravenous injection of penicillin Ⅱ cure staphylococcal endocarditis, caused by the abuse of liver poisoning. Case 38 A 38-year-old female, parenteral heroin and narcotic addicted patient. Due to dyspnea, cough, fever, chills, nausea, vomiting and admitted to hospital for 4 days. Denied the previous history of jaundice or hepatitis, also denied allergies, exposure to liver toxins or blood transfusion history. Body temperature 103 ° F. Left lung lung rales. White blood cell count 17,000 / mm ~ 3, 90% neutral, ESR (long tube method) 70mm / hour. Urine Check WBC 25 / High Power Mirror. See sputum check purple stained positive cocci, chest X-ray infiltration of the left lung. The day of admission, according to pneumonia and bacterial endocarditis treatment, intravenous injection of new penicillin Ⅱ 16g daily. A few days later, sputum and blood cultures were positive for Staphylococcus aureus. SGOT was 15IU (normal 5 ~ 40). The first 23 days of hospitalization, rose to 420IU. On the 28th day of hospitalization, Neoqing II treatment was stopped when transcutaneous liver biopsy was performed. At the start of clindamycin treatment, SGOT and SGPT continued to rise, at 1380 and 1164 IU, respectively,