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目的探讨急性肺栓塞(APE)患者血浆脑钠肽(BNP)和肌钙蛋白Ⅰ(cTnⅠ)水平对预后评估的价值。方法20例APE患者通过胸部增强螺旋CT、肺核素扫描、磁共振确诊。结果BNP>100pg/mL的患者共8例,BNP<100pg/mL的患者共12例,BNP升高组心源性休克发生率及院内死亡率均高于BNP正常组(P<0.05),且BNP水平与右心室舒张末内径显著相关(r=0.739)。cTnⅠ>0.05ng/mL的患者共9例,cTnⅠ<0.05ng/mL的患者共11例,cTnⅠ水平与APE患者心血管不良事件显著相关(OR=27.65,95%CI=4.67%～148.65%)。结论BNP和cTnⅠ可作为判断APE的预后指标,有助于明确危险分层,指导治疗。
Objective To investigate the prognostic value of plasma brain natriuretic peptide (BNP) and troponin Ⅰ (cTn Ⅰ) in patients with acute pulmonary embolism (APE). Methods Twenty patients with APE were diagnosed by thoracic enhanced spiral CT, pulmonary radionuclide scanning and magnetic resonance imaging. Results A total of 8 patients with BNP> 100 pg / mL had 12 patients with BNP <100 pg / mL. The incidence of cardiogenic shock and in-hospital mortality in BNP increased group was higher than that in normal BNP group (P <0.05) The level of BNP was significantly correlated with the end-diastolic diameter of the right ventricle (r = 0.739). There were 9 patients with cTnⅠ> 0.05ng / mL and 11 patients with cTnⅠ <0.05ng / mL. The level of cTnⅠwas significantly correlated with cardiovascular events (OR = 27.65,95% CI = 4.67% -148.65%) in APE patients. . Conclusion BNP and cTn Ⅰ can be used as a prognostic indicator of APE, which can help to clarify the risk stratification and guide the treatment.