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[目的]探讨氟尿嘧啶缓释剂(中人氟安)术中局部植入对进展期大肠癌的疗效。[方法]2004年8月至2008年2月64例进展期大肠癌患者行根治性手术,其中32例术中局部植入氟尿嘧啶缓释剂600mg(治疗组),32例术中以蒸馏水冲洗腹腔(对照组)。两组患者均随访2年,观察其毒副反应及2年生存率、局部复发率和远处转移率。[结果]治疗组的2年生存率、局部复发率均优于对照组(P<0.05);毒副反应及远处转移两组比较差异无统计学意义。[结论]术中局部植入氟尿嘧啶缓释剂效果明显,患者耐受性良好,是治疗进展期大肠癌的有效方法。
[Objective] To investigate the curative effect of local implantation of fluorouracil sustained-release agent (Fluoran) in advanced colorectal cancer. [Methods] From August 2004 to February 2008, 64 patients with advanced colorectal cancer underwent radical surgery. Among them, 32 patients received local implantation of fluorouracil sustained-release agent 600mg (treatment group), 32 patients were treated with distilled water to wash the abdominal cavity (Control group). Two groups of patients were followed up for 2 years to observe the toxicity and 2-year survival rate, local recurrence rate and distant metastasis rate. [Results] The two-year survival rate and the local recurrence rate in the treatment group were better than those in the control group (P <0.05). There was no significant difference between the two groups in the toxicity and distant metastasis. [Conclusion] The intraoperative local implantation of fluorouracil sustained-release agent is effective and the patients are well tolerated. It is an effective method for the treatment of advanced colorectal cancer.