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电刺激蓝斑核可抑制胃电和胃运动。我们先以6-羟基多巴胺(6-OHDA)损毁大鼠(已用乌拉坦麻醉)的灰部深翼肾上腺素能神经,然后观察了这种损坏对上述抑制效应的影响。结果表明,在对照组,电刺激蓝斑核导致胃电慢波的振幅和胃内压分别下降到对照值的42.31±9.79％和34.59±10.20％。但是,在注射6-OHDA组,刺激蓝斑核后胃电慢波的振幅和胃内压分别下降到对照值的84.14±10.13％和62.86±7.19％,注药组的抑制效应明显弱于对照组,(P<0.01)。本文结果提示:灰翼区肾上腺素能神经参与由刺激蓝斑核区引起的胃电和胃运动的抑制机制。
Electrical stimulation of the locus coeruleus inhibits gastric and gastric movements. We first destroyed the gray-fat adrenergic nerves of rats (having urethane anesthesia) with 6-hydroxydopamine (6-OHDA), and then observed the effect of this damage on the above inhibitory effects. The results showed that in the control group, the electric stimulation of the locus coeruleus caused the amplitude of gastric slow wave and intragastric pressure to drop to 42.31±9.79% and 34.59±10.20% of the control value, respectively. However, in the 6-OHDA group, the amplitude of the gastric slow wave and intragastric pressure decreased to 84.14±10.13% and 62.86±7.19% of the control values after stimulation of the locus coeruleus, respectively. The inhibitory effect of the injection group was significantly weaker than that of the control group. Group, (P < 0.01). The results of this study suggest that gray-winged adrenergic nerves participate in the mechanism of inhibition of gastric electrical and gastric motility caused by stimulation of the locus coeruleus.