论文部分内容阅读
目的探讨幽门螺杆菌(HP)在肝硬化门脉高压性胃病发生、发展中的作用及临床意义,观察HP感染与食管静脉曲张程度的关系。方法随机选取新乡市中心医院肝硬化门脉高压性胃病患者76例及同期在同医院经胃镜和组织学检查确诊为无肝病病史中的慢性胃炎和消化性溃疡患者87例,进行分析。结果肝硬化门脉高压组HP感染率为30.3%,显著低于慢性胃炎组的76.5%(P<0.05)和消化性溃疡组的83.3%(P<0.05)。门脉高压性胃病患者慢性活动性胃炎HP感染率为53.6%,非活动性胃炎HP感染率为16.7%,两者差异有统计学意义(P<0.05)。HP感染率随食管静脉曲张程度的增加而下降(无食管静脉曲张者HP阳性率为58.3%,有食管静脉曲张者HP阳性率为21.2%,P<0.05。)结论肝硬化门脉高压性胃病是一种独特类型的胃病,其发生与发展与HP感染无显著相关性;HP感染不是门脉高压性胃病的主要致病因素,但HP感染和门脉高压性胃胃病黏膜的慢性活动性胃炎密切相关;肝硬化门脉高压影响HP感染率。
Objective To investigate the role and clinical significance of Helicobacter pylori (HP) in the occurrence and development of portal hypertensive gastropathy in cirrhotic patients and to observe the relationship between HP infection and esophageal varices. Methods Seventy-six patients with portal hypertension caused by gastropathy of liver cirrhosis in Xinxiang Central Hospital and 87 patients with chronic gastritis and peptic ulcer were randomly selected from the same hospital in the history of non-liver disease by endoscopy and histology examination. Results The HP infection rate in cirrhotic patients with portal hypertension was 30.3%, significantly lower than 76.5% (P <0.05) in chronic gastritis group and 83.3% (P <0.05) in peptic ulcer group. The prevalence of HP in chronic active gastritis was 53.6% in patients with portal hypertensive gastropathy, and 16.7% in inactive gastritis. The difference was statistically significant (P <0.05). HP infection rate decreased with the degree of esophageal varices (positive rate of 58.3% without esophageal varices, positive rate of HP with esophageal varices was 21.2%, P <0.05) .Conclusion Liver cirrhosis with portal hypertensive gastropathy Is a unique type of gastric disease, its occurrence and development has no significant correlation with HP infection; HP infection is not the main causative factor of portal hypertensive gastropathy, but HP infection and chronic gastritis of portal hypertensive gastropathy mucosa Closely related; cirrhosis and portal hypertension affect HP infection rate.