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通过回顾分析相关文献和临床资料,就小儿重症肠道病毒(EV)71感染病例中单器官功能损害和多器官功能障碍的病理改变、发病机制、临床特点与防治方法进行探讨。小儿重症或危重症EV71感染病例中,通过病毒直接损伤致病、炎症损伤、免疫损伤、缺氧缺血性损伤、循环障碍、微循环和线粒体功能障碍等机制,既可能造成脑、肺、循环等单一器官、系统功能损害或障碍,又可能序贯累及多个器官而发展为多脏器功能障碍。对小儿重症或危重症EV71感染病例均应进行动态和持续的多器官功能监测,并遵循个体化、实施多器官功能保护和支持的综合救治原则。
Through retrospective analysis of relevant literatures and clinical data, the pathological changes, pathogenesis, clinical features and prevention and cure of single organ dysfunction and multiple organ dysfunction in children with severe enterovirus (EV) 71 infection were discussed. In children with severe or critically ill EV71 infection, brain, lung, and circulation may be caused by mechanisms such as pathogenicity of viral direct injury, inflammatory injury, immune damage, hypoxic-ischemic injury, circulatory disturbance, microcirculation and mitochondrial dysfunction Such as a single organ, system dysfunction or disorder, it may be sequential involving multiple organs and the development of multiple organ dysfunction. In children with severe or critically ill EV71 infection should be dynamic and continuous multi-organ function monitoring, and follow the individual, the implementation of multi-organ function protection and support of comprehensive treatment principles.