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急肝效灵是由丹参、赤芍、泽兰叶、茵陈、柴胡、大黄等十二味中药精制而成的复方制剂,我们用实验性肝损伤模型,通过酶学指标探讨了急肝效灵对肝损伤的有益作用。结果表明急肝效灵不同剂量组均有降低肝损伤后SGPT升高的作用,而以20g/kg组效果最为明显,能显著降低硫代乙酰胺及CCl4所致SGPT的升高并有减轻病理改变的作用。急肝效灵10g/kg,20g/kg组还能显著降低扑热息痛所致肝湿重的增高,有缓解炎性损伤的作用。以上结果表明急肝效灵对实验性肝损伤具有保护作用,可能是药物多成分多环节综合作用的结果。
Acute Hepatic Efficacy is a compound preparation made from 12 herbs including Salvia Miltiorrhiza, Radix Paeoniae Rubra, Zeelandia, Artemisia capillaris, Radix Bupleurum, and Rhubarb. We used an experimental hepatic injury model to explore acute liver disease through enzyme markers. Efficacy beneficial effects on liver damage. The results showed that different doses of Acute Hepatic Efficacy can reduce the increase of SGPT after liver injury, while the effect of 20g/kg group is the most obvious, which can significantly reduce the increase of SGPT caused by thioacetamide and CCl4 and reduce pathology. The role of change. Acute hepatic effect of 10g/kg, 20g/kg group can also significantly reduce the increase in liver weight caused by paracetamol, and have the effect of relieving inflammatory injury. The above results indicate that acute hepatic effect has protective effect on experimental hepatic injury, which may be the result of the multi-component and multi-component comprehensive effects of drugs.