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研究了胃十二指肠疾病患者胃窦粘膜胃泌素(Gas)、生长抑素(SS) 、P-物质(SP)的含量变化及其意义.结果表明:胃窦粘膜SS含量在胃溃疡组低于其余各组(P均<0.05),而在胃癌时则显著增高(P<0.001):SP浓度在十二指肠溃疡组显著低于其余各组(P均<0.05);胃癌患者Gas水平显著高于对照组(P<0.05);SS与SP在十二指肠溃疡时呈明显负相关.提示:胃粘膜中Gas、SS、SP的含量变化可能在胃十二指肠溃疡、胃癌的发病机理中起重要作用,SS有可能作为一项胃癌的辅助诊断指标.
(Gas), somatostatin (SS) and P-substance (SP) in the gastric mucosa of patients with gastroduodenal diseases were studied.The results showed that the contents of SS in the gastric mucosa of gastric antrum in gastric ulcer (P <0.05), but significantly higher in gastric cancer (P <0.001). The concentration of SP in duodenal ulcer group was significantly lower than that in other groups (all P <0.05) Gas level was significantly higher than that of the control group (P <0.05), SS and SP in the duodenal ulcer was significantly negative correlation, suggesting that: gastric mucosa Gas, SS, SP content may change in the gastroduodenal ulcer, The pathogenesis of gastric cancer plays an important role, SS may be used as a secondary diagnosis of gastric cancer.