NF-κB是一组重要的转录因子,参与细胞中多种生理过程,具有复杂的调节机制。近年来的研究发现NF-κB在在肿瘤发生发展过程中具有重要而且复杂的作用,总体来说,NF-κB通路的异常激活可导致一系列与肿瘤相关基因的异常表达,从而抑制肿瘤细胞凋亡,促进正常细胞转化及肿瘤血管形成和转移等,直接影响恶性肿瘤的发生和发展,其抑制剂的开发亦为肿瘤治疗提供了一种新的选择。 NF-κB is a group of important transcription factors involved in a variety of physiological processes in the cell, with complex regulatory mechanisms. In recent years, the study found that NF-κB plays an important and complex role in tumorigenesis. In general, abnormal activation of NF-κB pathway can lead to abnormal expression of a series of tumor-related genes, thereby inhibiting tumor cell apoptosis Promote normal cell transformation and tumor angiogenesis and metastasis, which directly affects the occurrence and development of malignant tumors. The development of its inhibitors also provides a new choice for the treatment of cancer.