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目的探讨阿托伐他汀对原发性高血压(EH)患者血清内皮素(ET)和一氧化氮(NO)含量的影响。方法 80例EH患者随机分为常规治疗组(常规降压治疗,40例)及阿托伐他汀组(常规降压药物+阿托伐他汀治疗3个月,40例),另选取30例年龄与性别相匹配的健康者体检者为正常对照组。检测各组治疗前后血清ET和NO水平。结果 EH患者治疗前ET水平明显高于正常对照组(P<0.01),NO明显低于正常对照组(P<0.01);治疗后EH患者ET水平明显低于治疗前(P<0.05),NO明显高于治疗前(P<0.05);阿托伐他汀组与常规治疗组比较ET降低和NO升高更为明显(P<0.05)。结论 EH患者应用阿托伐他汀治疗可进一步改善EH患者的血管内皮功能。
Objective To investigate the effect of atorvastatin on serum endothelin (ET) and nitric oxide (NO) in patients with essential hypertension (EH). Methods Eighty patients with EH were randomly divided into routine treatment group (n = 40) and atorvastatin group (n = 40) with conventional antihypertensive drugs and atorvastatin. Another 30 patients Sex matched healthy subjects were normal control group. The levels of serum ET and NO in each group before and after treatment were detected. Results The level of ET in EH patients before treatment was significantly higher than that in the normal control group (P <0.01), and the NO level in EH patients was significantly lower than that in the normal control group (P <0.01) (P <0.05). Compared with conventional treatment group, ET decreased and NO increased more significantly in atorvastatin group (P <0.05). Conclusions Atorvastatin treatment in EH patients can further improve the endothelial function of EH patients.