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采用Ｇｏｌｏｍｂｏ－Ｅ手术方法造模，建立兔膝关节骨关节炎模型，对中药益肾蠲痹液离子导入法的治疗作用和疗效进行了实验观察。实验设实验组和对照组，每组用新西兰兔１５只。通过对实验动物膝关节活动情况、关节液检测、Ｘ线摄片和大体标本的观察，以及关节软骨组织细胞的光镜及透视电镜观察。结果显示，实验组临床改变、实验室检查及软骨组织修复等方面均明显优于对照组（Ｐ＜０．０５或Ｐ＜０．０１）。说明中药电离子导入治疗骨性关节软骨病变具有良好的作用。
The Golombo-E operation was used to establish a model of knee osteoarthritis in rabbits. The therapeutic effect and therapeutic effect of Yishen Bi paraquat by iontophoresis were observed. Experiment set experimental group and control group, each group with 15 New Zealand rabbits. Through the knee joint activities of animals, synovial fluid test, X-ray and gross specimens were observed, as well as articular cartilage cells were observed by light microscopy and electron microscopy. The results showed that the clinical changes in the experimental group, laboratory tests and cartilage tissue repair were significantly better than the control group (P <0.05 or P <0.01). Description of Chinese medicine iontophoresis treatment of osteoarthritis cartilage disease has a good effect.