Based on the N-S equation, taking the character of thermal and saline stratified flow into account, and considering the effects of buoyancy on turbulence, the k-ε model of thermal and saline stratified flow is established.Density stratified flow with both the vertical temperature gradient and the vertical salinity gradient is simulated numerically, in which turbulent terms are calculated by the k-ε turbulent model.The distributions of velocity, temperature and salinity are given in this paper.The feature of stratification and turbulence is described correctly by the model.The computational results agree well with the experimental data.