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本文报告了22例早期胃癌和癌旁病变,共有癌灶28个(3例多灶性癌)的粘液组化和超微结构观察。本组合并慢性萎缩性胃炎(85.93％)、肠化(81.22％)和中度及重度不典型增生(78.59％)。这些高发病变与早期胃癌发生有密切关系。从AB-PAS和HID染色结果,肠型癌灶20个(71.42％)、胃型癌灶5个(17.85％)和混合型癌灶3个(10.71％),结果表明人肠化在胃癌发生有重要意义。电镜观察肠型癌含有与癌旁肠化杯状细胞的粘液颗粒及微绒毛,显示肠化与胃癌发生密切相关。重度不典型增生上皮有类似癌细胞超微结构改变,提示不典型增生细胞是癌前病变。
In this paper, 22 cases of early gastric cancer and paracancerous lesions were reported. There were 28 cases (3 cases of multifocal cancers) with mucin histochemistry and ultrastructure observation. The combination of chronic atrophic gastritis (85.93%), intestinal metaplasia (81.22%) and moderate and severe dysplasia (78.59%). These high incidence lesions are closely related to the occurrence of early gastric cancer. From AB-PAS and HID staining results, there were 20 (71.42%) intestinal type lesions, 5 (17.85%) gastric type lesions, and 3 (10.71%) mixed type lesions. The results showed that human intestinal metaplasia occurred in gastric cancer. There’s important meaning. Electron microscopy showed that intestinal type carcinomas contained mucinous particles and microvilli in the adjacent paracancerous goblet cells, indicating that intestinal metaplasia was closely related to gastric cancer. Severe dysplasia epithelium has similar ultrastructural changes in cancer cells, suggesting that atypical hyperplasia is a precancerous lesion.