随着医学影像学的发展，冠状动脉介入诊疗术的应用日益普遍，需要经常应用大剂量含碘造影剂，因此，造影剂肾病的发病率逐渐增加，目前造影剂肾病已成为医院获得性急性肾损伤的第三位致病因素，是冠状动脉诊疗术的常见并发症。如何防治冠状动脉介入诊疗过程中引发的造影剂肾病逐渐受到心血管介入医生的重视，早期诊断并及时采取有效措施对于造影剂肾病的发生及病情转归至关重要。现就造影剂肾病的发病机制、危险因素、中性粒细胞明胶酶相关性载脂蛋白在造影剂肾病的预测作用以及防治的研究进展做一综述。“,”With the development of medical imaging ,percutaneous coronary intervention therapy is increasingly applied and often re-quires the application of large doses of an iodine contrast agent .Therefore,the incidence rate of contrast induced nephropathy (CIN) has also gradually increased .Currently CIN has become the hospital acute kidney injury of the three pathogenic factors and is a common complication of coronary diagnosis and treatment operation .How to prevent ,treat and cure the CIN caused by coronary intervention in the diagnosis and treatment of the disease has gradually gained the attention of doctors .Early diagnosis and timely effective measures for this occurrence and the prognosis of the disease is very important .In this paper,the pathogenesis,risk factors,and the predictive effects of NGAL in CIN and the re-search progress in the prevention and treatment of CIN were reviewed .