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本文调查的17例慢性乙型肝炎,均系 HBeAg及抗 HBe 两者阴性期(e 空缺阶段)持续时间2年以上者,其中男15例,女2例,平均年龄50.2±15.1岁,平均观察时间7.0±4.5年,e 空缺阶段平均观察时间3.7±1.2年。HBsAg 效价低于2~2以下者8例(A组),其值量波动性变化者9例(B 组),两组患者年龄及男女之比,以及观察时间均无显著差别。作者对两组患者肝组织学和肝功能以及血清 HBsAg值的动态变化作了对比研究。结果①e 空缺阶段17例初次肝活检组织学诊断为肝硬化(LC)6例(35%),慢性活动性肝炎
17 cases of chronic hepatitis B were investigated in this study, both of HBeAg and anti-HBe negative period (e vacancy phase) duration of more than 2 years, including 15 males and 2 females, mean age 50.2 ± 15.1 years, the average observed Time 7.0 ± 4.5 years, e vacancy phase average observation time 3.7 ± 1.2 years. There were 8 cases (group A) whose HBsAg titer was lower than 2 ~ 2, and 9 cases (group B) whose fluctuation of the value were different. There was no significant difference in the age and the ratio between men and women and the observation time. The author of the two groups of patients with liver histology and liver function and serum HBsAg value of the dynamic changes were compared. Results ① The vacancy phase 17 cases of primary liver biopsy histological diagnosis of cirrhosis (LC) in 6 cases (35%), chronic active hepatitis