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目的回顾性分析于2006年11月至2008年7月进行的食蟹猴同种异体肾移植术180例的资料,总结食蟹猴肾移植术后并发尿漏的原因、处理经验与教训。方法食蟹猴180例,雄性,年龄3～5岁,体重(4.3±0.69kg)。配好型的两只动物互为供体和受体。使用盐酸氯胺酮和速眠新各0.1mL/kg肌注麻醉。供体左肾被摘除后使用4℃的Euro-Collins灌注并保存,时间不超过30min。用8-0的缝合线将供体肾动脉端侧缝合到受体腹主动脉,供体肾静脉缝合到受体下腔静脉。将供体输尿管与受体右侧输尿管端端吻合。结果和结论 180例肾移植模型共发生术后并发症24例,其中尿漏7例,占各种术后并发症的29.17%。发生时间为肾移植术后第5至11天,均伴随有肌酐值的显著升高。
Objective To retrospectively analyze the data of 180 cases of cynomolgus kidney allograft from November 2006 to July 2008 to summarize the causes and treatment experiences of urine leakage after cynomolgus monkey kidney transplantation. Methods Cynomolgus monkey 180 cases, male, aged 3 to 5 years old, body weight (4.3 ± 0.69kg). Two animals with a good type of donor and recipient each other. Ketamine hydrochloride and hypnosis new 0.1mL / kg intramuscular injection anesthesia. Donor left kidney was removed and perfused with Euro-Collins at 4 ° C for less than 30 min. The donor renal artery was sutured to the recipient abdominal aorta with a suture of 8-0 and the donor’s renal vein was sutured into the recipient’s inferior vena cava. The donor ureter and the right ureter end of the recipient anastomosis. RESULTS AND CONCLUSION: There were 24 cases of postoperative complications in 180 cases of renal transplantation, including 7 cases of urinary leakage, accounting for 29.17% of all postoperative complications. Occurring for renal transplantation after 5 to 11 days, were accompanied by a significant increase in creatinine.