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目的分析腋窝淋巴结阴性乳腺癌患者的临床特点、治疗方法对预后的影响。方法收集普外科治疗的48例腋窝淋巴结阴性乳腺癌患者的临床资料,采用Kaplan-Meier曲线分析和多因素回归分析方法,对患者的生存情况及预后影响因素进行分析。结果单因素分析发现,年龄、淋巴结清扫数目、肿瘤大小、内分泌治疗与否、ER表达差异有统计学意义(P<0.05)。将5个有统计学意义的单因素作为自变量,患者的无瘤生存时间作为应变量,采用Cox比例风险回归模型多因素分析,淋巴结清扫数目、肿瘤大小、内分泌治疗是淋巴结阴性乳腺癌患者预后的独立影响因素(P<0.05)。结论原发肿瘤的大小和腋窝淋巴结清扫数目可评价病理分期的准确性,对于较大的乳腺癌患者应行较为彻底的淋巴结清扫。
Objective To analyze the clinical characteristics of patients with axillary lymph node-negative breast cancer and the effect of treatment on the prognosis. Methods The clinical data of 48 patients with axillary lymph node-negative breast cancer who were treated by general surgery were collected. Kaplan-Meier curve analysis and multivariate regression analysis were used to analyze the patients’ survival and prognostic factors. Results Univariate analysis showed that age, number of lymph node dissection, tumor size, endocrine therapy or not, ER expression was statistically significant (P <0.05). The five statistically significant single-factor as independent variables, the patient’s tumor-free survival time as a dependent variable, using Cox proportional hazards regression model multivariate analysis, the number of lymph node dissection, tumor size, endocrine therapy is lymph node-negative breast cancer prognosis Independent factors (P <0.05). Conclusion The size of the primary tumor and the number of axillary lymph node dissection can evaluate the accuracy of pathological staging, and for patients with large breast cancer more thorough lymphadenectomy should be performed.