《Med News》1983;15(35):6. 吡哆醇缺乏能引起周围神经病,但是根据最近关于7名病人的报告,吡哆醇过量也能引起此病。这7名病人在服用大剂量维生素B_6后发生了进行性感觉性共济失调,深部远侧肢体的位置感缺失和振颤感。这些病人服用吡哆醇3—40个月,每天最大剂量为2—6克。4名病人因月经前水肿而服药(其中2名是自己服药,2名是妇科医生的建议),2名病人是自己加在膳食中作为补充 Med News 1983; 15 (35): 6. Pyridoxine deficiency can cause peripheral neuropathy, but according to a recent report on seven patients, an excess of pyridoxine can also cause the disease. The seven patients developed progressive ataxia after taking high doses of vitamin B_6, a loss of sense of location and a sense of agitation in the deep distal limbs. These patients take pyridoxine 3-40 months, the maximum daily dose of 2-6 grams. Four patients took medication for pre-menstrual edema (two were on their own and two were advised by a gynecologist) and two patients added themselves to the diet as a supplement