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研究膀胱癌患者膀胱部分切除后不同药物的灌注疗效。方法 :1 6 3例膀胱癌术后患者分对照组、噻替哌组 (TsPa)、卡介苗组 (BCG)、丝裂霉素组 (MMC)、表柔比星组 (EPI) ;术后d 7经导尿管膀胱内灌注 ,除EPI5 0mg仅灌一次外 ,TsPa 6 0mg、BCG 6 0mg、MMC 2 0mg均为 1次 周× 8次 ,然后 1次 月× 1 0次 ,共 1年 ,对照组仅为术后患者。随访 6月— 6年。结果 :与其他组相比 ,对照组、TsPa组复发率高 (P <0 0 1 ) ;TsPa、BCG毒副作用强 (P <0 0 1 ) ;MMC费用高 (P <0 0 1 )。结论 :膀胱癌患者膀胱部分切除术后 ;表柔比星灌注疗效好 ,费用低
To study the perfusion effects of different drugs after bladder resection in patients with bladder cancer. Methods: One hundred and sixty-three cases of postoperative bladder cancer patients were divided into control group, Tspa group, BCG group, MMC group and EPI group. 7 intravesical instillation of catheter, except EPI5 0mg only once, TsPa 6 0mg, BCG 6 0mg, MMC 20mg are 1 times × 8 times, then 1 times × 10 times a total of 1 year, Control group only postoperative patients. Follow-up from 6 months to 6 years. Results: Compared with other groups, the recurrence rate was higher in the control group and the TsPa group (P <0.01). TsPa and BCG were more toxic (P <0.01) and the MMC cost was higher (P <0.01). Conclusion: Bladder cancer patients after partial resection of the bladder; epirubicin perfusion effect, low cost