论文部分内容阅读
报道了阿莫西林对照品与阿莫西林胶囊的常规拉曼光谱(NRS)和在银胶基底上溶液的表面增强拉曼光谱(SERS),归属了各个振动峰位和增强峰位;研究了阿莫西林对照品溶液与DNA相互作用的荧光光谱和表面增强拉曼光谱。结果表明:阿莫西林胶囊与阿莫西林对照品的NRS及SERS图谱基本一致,说明胶囊中的辅料对阿莫西林的检测几乎没有影响;在SERS中,阿莫西林分子是通过氮原子和苯环平行吸附在银纳米表面;阿莫西林分子与DNA相互作用的主要键合模式是插入作用,阿莫西林中的苯环和氮原子插入到DNA双螺旋结构的碱基对之间,为深入了解此类药物的作用机理提供了十分重要的信息和有益的参考。
Reported the conventional Raman spectroscopy (NRS) of amoxicillin and amoxicillin capsules and the surface-enhanced Raman spectroscopy (SERS) of solutions on silver-plastic substrates, which were attributed to each vibration peak and enhancement peak. Fluorescence Spectroscopy and Surface Enhanced Raman Spectroscopy of Amoxicillin Reference Solution Interacting with DNA. The results showed that: the amoxicillin capsules and amoxicillin reference substance NRS and SERS map basically the same, indicating that the capsules in the detection of amoxicillin has almost no effect; in SERS, amoxicillin molecules through the nitrogen atom and benzene Ring parallel adsorption on the silver nano surface; amoxicillin molecules and DNA interaction is the main bonding mode of insertion, amoxicillin in the benzene ring and nitrogen atoms inserted into the DNA double helix structure between the base pairs, for further Understanding the mechanism of action of these drugs provides very important information and useful reference.