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中药蜜丸为常用的传统剂型之一,其用生粉制丸体积及用量较大,化学成分复杂,无论从原料本身还是从制备的全过程来看,若能在确保不受微生质污染的同时,又可确保药丸的药理活性、柔软性、含水量均不受影响,在工艺上讲是一个相当难的问题。长期以来,由于在蜜丸的制备和保存中的多种因素,致使其微生物污染严重。这不仅造成经济上的损失,还不利于安全有效地使用药品。一方面污染的细菌可使药品变质,另一方面其本身就有一定的致病性。中药蜜丸的细菌污染与生产的每个环节及应用前的整个过程有着关系,概括起来有以下几点。
Traditional Chinese medicine honey pill is one of the traditional traditional dosage forms. Its volume and dosage are larger with the use of raw meal, and the chemical composition is complex. No matter from the raw material itself or from the whole process of preparation, it can be ensured that it will not be contaminated by microorganisms. At the same time, it can ensure that the pharmacological activity, softness and moisture content of the pill are not affected, and it is a very difficult problem in terms of process. For a long time, due to various factors in the preparation and preservation of honeyed pills, the microbial contamination has been severe. This not only causes economic losses, but also does not facilitate the safe and effective use of drugs. On the one hand, the contaminated bacteria can degenerate the drug, on the other hand, it itself has certain pathogenicity. The bacterial contamination of the honey pill of Chinese medicine is related to every link in production and the whole process before application. The following points are summarized.