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Ｔ 辅助细胞（ＴＨ）可分为ＴＨ１ 和ＴＨ２ 两类功能不同的亚群。在同种移植中，ＴＨ１ 细胞参与排斥反应，而ＴＨ２ 细胞通过下调ＴＨ１ 细胞功能促使移植耐受。通过调节细胞因子网络干预ＴＨ１／ＴＨ２ 转换（即ＴＨ１ 向ＴＨ２ 偏离），将可诱导移植耐受。本文还对ＴＨ１／ＴＨ２ 转换学说存在的争议及其原因进行了探讨。
T helper cells (TH) can be divided into TH1 and TH2 two types of different functions of the subgroups. In allotransplantation, TH1 cells are involved in rejection and TH2 cells promote engraftment by down-regulating TH1 cell function. Transplantation tolerance can be induced by regulating the cytokine network to intervene in the TH1 / TH2 transition (ie TH1 to TH2 deviations). This article also discusses the existing controversies and reasons of TH1 / TH2 conversion theory.