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目的探讨影响结直肠癌术后患者预后的因素。方法回顾性分析469例结直肠癌患者的临床病理及生存随访资料。采用Cox回归模型分析性别、年龄、肿瘤直径大小、浸润深度、分化程度、淋巴结转移情况、TNM分期、癌胚抗原(CEA)、糖类抗原(CA125、CA199)与预后的关系。结果性别、年龄、肿瘤直径大小与结直肠癌术后患者预后均无关(P>0.05);分化程度、浸润深度、淋巴结转移、TNM分期、CEA、CA-125均与结直肠癌术后患者预后密切相关,且差异有统计学意义(P<0.01)。结论分化程度、浸润深度、淋巴结转移、TNM分期、CEA、CA-125均可作为结直肠癌术后患者预后的主要危险因素之一。
Objective To investigate the prognostic factors of postoperative colorectal cancer patients. Methods A retrospective analysis of 469 cases of colorectal cancer patients with clinical pathology and survival follow-up data. Cox regression model was used to analyze the relationship between gender, age, tumor size, depth of invasion, degree of differentiation, lymph node metastasis, TNM stage, carcinoembryonic antigen (CEA), carbohydrate antigen (CA125, CA199) Results There was no correlation between gender, age and tumor size in patients with colorectal cancer (P> 0.05). The degree of differentiation, depth of invasion, lymph node metastasis, TNM stage, CEA and CA-125 were all significantly correlated with the prognosis of patients with colorectal cancer Closely related, and the difference was statistically significant (P <0.01). Conclusion The degree of differentiation, depth of invasion, lymph node metastasis, TNM staging, CEA and CA-125 may be one of the major risk factors for postoperative prognosis of patients with colorectal cancer.