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目的:探讨血清β_2-微球蛋白及血清Ⅲ型前胶原含量与肝炎临床病理变化的关系。方法:对110例急、慢性肝炎及肝炎后肝硬化患者行肝活检,病理变化用Knodell组织学活动指数(HAI)标准记分判定,同时用RIA法测定血清β_2-微球蛋白(β_2-M)及血清Ⅲ型前胶原(PCⅢ)含量,将组织学变化与血清学指标进行相关分析。结果:血清β_2-M含量与肝细胞坏死范围及炎性细胞浸润程度相关(r=0.670,P<0.01),血清PCⅢ含量与肝纤维化程度相关(r=0.668,P<0.01)。结论:血清β_2-M和PCⅢ含量变化分别是反映肝实质炎症活动程度和肝纤维化程度的有价值指标。
Objective: To investigate the relationship between serum β_2-microglobulin and serum type Ⅲ procollagen and the clinicopathological changes of hepatitis. Methods: One hundred and ten patients with acute and chronic hepatitis and posthepatitic cirrhosis were examined by liver biopsy. Pathological changes were determined by Knodell histological activity index (HAI) standard score. Serum β_2-microglobulin (β_2-M) And serum type Ⅲ procollagen (PC Ⅲ) content, histological changes and serological indicators were analyzed. Results: Serum β_2-M level correlated with the extent of hepatocellular necrosis and inflammatory cell infiltration (r = 0.670, P <0.01). Serum PCⅢ level correlated with the degree of liver fibrosis (r = 0.668, P <0.01). Conclusion: The changes of serum β_2-M and PCⅢ levels are valuable indices reflecting the degree of hepatic parenchymal inflammation and liver fibrosis, respectively.