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重症肌无力的病因不明。常可见到本病有体液免疫和细胞免疫功能的异常以及胸腺的病理改变。因此,免疫抑制疗法可能有效。资料和方法10例重症肌无力患者,平均年龄37岁。全部病人都是进行性加重,对抗胆碱酯酶剂效果不佳。其中5例使用本疗法之前8个月～15年已作过胸腺切除术。在用抗胸腺细胞球蛋白(ATG)治疗的过程中有2例并用了硫唑嘌呤(2mg/kg/日),另1例并用了强的松(10～30mg/日)。ATG是用人的胸腺细胞免疫山羊血制成。人的胸腺细胞得自胎儿或10岁以下的儿童。应用下列方法制作:取10~9只人胸腺细胞混以弗氏佐剂,每周分3次给羊作皮下注射。最后作成的ATG试剂为每100ml羊免疫球蛋白G中
The cause of myasthenia gravis is unknown. Often can be seen in this disease have humoral and cellular immune function abnormalities and thymus pathological changes. Therefore, immunosuppressive therapy may be effective. Materials and Methods 10 cases of myasthenia gravis patients, mean age 37 years old. All patients are progressive increase, antagonistic effect of cholinesterase poor. Five of the 5 patients had thymectomy 8 to 15 years prior to using this therapy. In the treatment with anti-thymocyte globulin (ATG) in 2 cases and the use of azathioprine (2mg / kg / day), and the other 1 case and the use of prednisone (10 ~ 30mg / day). ATG is made from human goat’s blood that is immunized with human thymocytes. Human thymocytes are obtained from the fetus or children under 10 years of age. Application of the following methods: Take 10 to 9 human thymocytes mixed with Freund’s adjuvant, three times a week for subcutaneous injection of sheep. The final ATG reagent is made per 100 ml of sheep immunoglobulin G.