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本文对388例胃粘膜活检标本进行了形态学观察,发现有34.8%的病例呈现腺内套管,以胃息肉、萎缩性胃炎和管状腺癌为多见。根据套管上皮细胞的增生程度分为不伴异型性增生套管和异型增生套管两种,P21蛋白在不伴异型性增生套管中均为阴性表达,异型增生套管上皮细胞中用性表达47.9%;CEA(癌胚抗原)在不伴异型性增生套管上皮细胞中阳性表达为13.3%,异型增生套管上皮细胞中阳性表达高达68.8%。结果提示不伴异型性增生套管是一种良性增生性病变,异型增生套管则是重要的癌前期病变。
In this paper, 388 cases of gastric mucosal biopsy specimens were observed morphologically, found that 34.8% of cases showed intrahepatic casing, with polyps, atrophic gastritis and tubular adenocarcinoma is more common. According to the degree of proliferation of the epithelial cells of the bifurcation, there were two types of non-proliferative and non-proliferative bushing. P21 protein was negatively expressed in the non-heterogeneous bushing, while in the dysplastic biliary epithelial cells (47.9%). The positive rate of CEA (carcinoembryonic antigen) was 13.3% in epithelial cells without dysplasia and 68.8% in dysplastic epithelial cells. The results suggest that non-dysplastic bushing is a benign proliferative disease, dysplastic bushing is an important precancerous lesions.