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目的:观察盐酸沙格雷酯治疗糖尿病合并微量蛋白尿的临床疗效。方法:将2008～2011年期间住院的糖尿病合并微量蛋白尿患者178例随机分为2组,治疗组108例,对照组70例,比较两组患者治疗前后微量蛋白尿排泄率。结果:治疗组2周后微量蛋白尿有下降趋势,对照组无下降,但两组间差异无统计学意义;治疗组12周后较对照组微量蛋白尿排泄率明显下降(P<0.001)。结论:沙格雷酯长期应用对治疗糖尿病微量蛋白尿有显著疗效。
Objective: To observe the clinical effect of sarpogrelate hydrochloride in the treatment of diabetic patients with microalbuminuria. Methods: A total of 178 diabetic patients with microalbuminuria who were hospitalized during 2008-2011 were randomly divided into two groups: 108 cases in the treatment group and 70 cases in the control group. Microprotein excretion rate was compared between the two groups before and after treatment. Results: After 2 weeks, the microalbuminuria of the treatment group showed a downward trend, while the control group did not decrease. However, there was no significant difference between the two groups. The excretion rate of microalbuminuria in the treatment group after 12 weeks was significantly lower than that in the control group (P <0.001). Conclusion: The long-term application of sarlegiride has a significant effect on the treatment of diabetic microalbuminuria.