治疗药物监测(TDM)是近十年崛起的一门新的边缘学科,其目的是通过测定体液中药物浓度并利用药物动力学原理使给药方案个体化,以提高疗效,避免或减少毒副反应。因此,TDM测定结果的准确性直接影响剂量的调整和疗效。 笔者近来发现在使用标准品或对照品做标准曲线时存在着不容忽视的问题。有些文章常以药物的盐为标准品或对照品,配成浓度梯度,以药物盐的浓度(μg/ml)和测定值作回归方 Therapeutic drug monitoring (TDM) is a new fringe discipline that has emerged in the recent decade. Its purpose is to personalize drug regimens by determining drug concentration in body fluids and using pharmacokinetic principles to improve efficacy and avoid or reduce toxicity reaction. Therefore, the accuracy of TDM measurement results directly affect dose adjustment and efficacy. I recently found that there is a problem that can not be ignored in the use of standard or reference standard curve. Some articles often drug salt as a standard or reference substance, dubbed the concentration gradient, the concentration of drug salts (g / ml) and the measured value for regression