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目的 探讨国内首创的OUR QGD全身伽玛刀治疗头、颈、胸、腹、盆腔内肿瘤的疗效。方法 应用OUR QGD全身伽玛刀治疗头、颈、胸、腹、盆腔内肿瘤 1168例 ,男 82 2例 ,女 3 46例 ,其中肺癌 664例。应用西门子SOMATOM Espring型螺旋CT行薄层扫描 ,获得定位图像 ,在γ TPS治疗规划系统上进行三维图像重建、显示 ;根据肿瘤性质、类型、部位及脑干、脊髓、血管、神经、气管、食管、胃、肠、膀胱的毗邻关系制订适合的治疗计划 ,再行治疗方案的模拟显示 ,评估、修正、确定最佳治疗方案。结果 在 70 2例随访复查资料完整的病例中 ,伽玛刀治疗后 3～ 6个月复查评价其近期疗效 ,肿瘤局部控制率 (CR +PR) 91 7% (64 4/70 2 ) ;症状、体征的改善率为 90 9%。放射性食管炎、放射性肺炎、放射性肠炎等并发症仅 8 3 % ,未见穿孔致死等严重并发症病例。 1年、2年生存率正在统计中。结论 伽玛刀治疗全身肿瘤等病变是一种安全、有效 ,并发症较少的方法。采用放化疗配合伽玛刀进行综合治疗疗效更好 ,更为合理。
Objective To investigate the curative effect of the first OUR QGD Gamma Knife in the treatment of head, neck, chest, abdomen and pelvic tumors. Methods A total of 1168 patients with head, neck, thorax, abdomen and pelvic tumors were treated with OUR QGD whole body gamma knife. There were 82 male and 3246 female patients, of which 664 were lung cancer. Application of Siemens SOMATOM Espring spiral CT thin layer scan to obtain the positioning image, in the γ TPS treatment planning system for three-dimensional image reconstruction, display; according to tumor nature, type, location and brain stem, spinal cord, blood vessels, nerves, trachea, esophagus , Stomach, intestine, bladder adjacent to the development of appropriate treatment plan, re-treatment program simulation shows that assessment, correction, to determine the best treatment. Results Among the 70 2 cases with complete follow-up data, the short-term curative effect was evaluated 3 to 6 months after gamma knife treatment. The local control rate (CR) was 91.7% (64 4/70 2). The symptoms , Signs of improvement rate of 90 9%. Radiation esophagitis, radiation pneumonitis, radiation enteritis and other complications was only 83%, no serious complications such as perforation fatal cases. 1 year, 2 year survival rate is statistics. Conclusion Gamma knife treatment of systemic tumors and other lesions is a safe, effective, less complications. The use of radiotherapy and chemotherapy with gamma knife for comprehensive treatment of better, more reasonable.