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目的了解本市泌尿生殖道感染患者支原体感染及耐药状况,为临床诊治提供依据。方法对1846例疑似泌尿生殖道感染患者采取标本进行支原体培养和药敏试验,对结果统计分析。结果共培养出支原体802例(株),阳性率43.4%;单独解脲脲原体(Uu)阳性669例,阳性率36.2%;单独人型支原体(Mh)阳性80例,阳性率4.3%;Uu+Mh阳性147例,阳性率8.0%。男、女患者阳性率分别为24.0%和61.2%,两者差异显著(P<0.01)。单独Uu阳性对环丙沙星耐药率最高为80.4%,对交沙霉素、强力霉素、克拉霉素、美满霉素敏感率分别为95.2%、89.2%、87.7%、84.2%;Uu+Mh阳性对罗红霉素、阿奇霉素、克拉霉素、螺旋霉素耐药率>80%,对交沙霉素、强力霉素、美满霉素敏感率分别为66.0%、61.2%、53.1%。结论泌尿生殖道支原体感染主要由Uu引起,女性感染多见。Uu与Uu+Mh混合有不同的耐药谱,Uu+Mh混合感染对抗生素的耐药性增强;交沙霉素、强力霉素可作为治疗支原体感染的首选药物。
Objective To understand the mycoplasma infection and drug resistance in patients with genitourinary tract infections in this city and provide the basis for clinical diagnosis and treatment. Methods 1846 cases of suspected genitourinary tract infection in patients with specimens for mycoplasma culture and drug susceptibility tests, the results of statistical analysis. Results A total of 802 mycoplasmas were obtained. The positive rate was 43.4%. The positive rate of Uu was 669, the positive rate was 36.2%. The positive rate of Mycoplasma hominis was 4.3%. 147 cases of Uu + Mh positive, the positive rate of 8.0%. The positive rates of male and female patients were 24.0% and 61.2% respectively, with significant difference (P <0.01). The highest rate of resistance to ciprofloxacin alone was 80.4% for Uu positive, and 95.2%, 89.2%, 87.7% and 84.2% for josamycin, doxycycline, clarithromycin and minocycline respectively. Uu + Mh positive for roxithromycin, azithromycin, clarithromycin, spiramycin resistance rate of> 80%, josamycin, doxycycline, minocycline sensitivity were 66.0%, 61.2%, 53.1% . Conclusion Mycoplasma genital tract infection is mainly caused by Uu, and female infection is more common. Uu and Uu + Mh mixed with different drug resistance spectrum, Uu + Mh mixed infection increased antibiotic resistance; jasamycin, doxycycline can be used as the treatment of mycoplasma infection drug of choice.