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目的:探讨女贞子对脊髓损伤大鼠的神经保护作用。方法:采用改良Allen法造模,随机分为假手术组、模型组和治疗组,每组30只。在造模成功后6个时间点(1h、6h、24h、3天、6天、14天)取出脊髓标本,检测脊髓组织中热休克蛋白70(HSP70)的表达,造模后6h测定脊髓组织中超氧化物歧化酶(SOD)和丙二醛(MDA)的含量。结果:治疗组脊髓组织中HSP70的表达在所有时间点较模型组明显增强(P<0.05),且表达高峰提前至1天;治疗组于损伤后6h,SOD高于模型组,MDA低于模型组,与模型组比较,差异均有显著性意义(P<0.05)。结论:女贞子在脊髓损伤早期有效清除自由基,显著增强损伤部位HSP70的表达,保护脊髓神经组织。
Objective: To investigate the neuroprotective effects of Ligustrum lucidum on rats with spinal cord injury. Methods: A modified Allen method was used to establish the model. The rats were randomly divided into sham operation group, model group and treatment group, 30 in each group. Spinal cord specimens were removed at 6 time points (1 h, 6 h, 24 h, 3 days, 6 days, 14 days) after successful modeling to detect the expression of HSP70 in the spinal cord tissue. The spinal cord tissue In the content of superoxide dismutase (SOD) and malondialdehyde (MDA). Results: The expression of HSP70 in the spinal cord tissue of the treated group was significantly higher than that of the model group at all time points (P <0.05), and the expression peak was advanced to 1 day. At 6 hours after injury, the SOD in the treated group was higher than that in the untreated group Group, compared with the model group, the difference was significant (P <0.05). Conclusion: Ligustrum lucidum can effectively scavenge free radicals in the early stage of spinal cord injury, enhance the expression of HSP70 and protect the spinal nerves.