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目的:探讨CD44v6和E-上皮钙黏附素(E-cadherin,ED)表达与胆管癌生物学行为的关系。方法:用催化信号放大免疫组化方法,检测43例胆管癌组织中CD44v6和ED蛋白表达,综合分析了CD44v6和ED蛋白表达与胆管癌临床病理因素间的关系。结果:在胆管癌组织中,CD44v6和ED表达阳性率分别为63%和53%。CD44v6高表达、ED低表达与胆管癌的TNM分期、分化程度和转移密切相关(P<0.05)。结论:CD44v6和ED表达提示胆管癌生物学行为不良。
Objective: To investigate the relationship between the expression of CD44v6 and E-cadherin (ED) and the biological behavior of cholangiocarcinoma. Methods: The expressions of CD44v6 and ED in 43 cases of cholangiocarcinoma were detected by the method of catalytic signal amplification and immunohistochemistry. The relationship between the expression of CD44v6 and ED and the clinicopathological factors of cholangiocarcinoma was analyzed. Results: The positive rates of CD44v6 and ED in cholangiocarcinoma were 63% and 53% respectively. CD44v6 overexpression and ED low expression were closely related to TNM staging, differentiation and metastasis of cholangiocarcinoma (P <0.05). Conclusion: The expressions of CD44v6 and ED suggest poor biological behavior of cholangiocarcinoma.