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本实验应用五种化学性质截然不同的止孕剂,揭示了小白鼠在妊娠各期药物止孕情况的变化过程。这个变化过程不因药物更改而改变,而是取决于小白鼠自身的止孕生理特性。小白鼠妊娠各期止孕变化过程可分为三个阶段。第一阶段,约在怀孕10天之内,药物杀死胚胎之后,胚胎无排出现象而留在子宫中吸收。第二阶段是在怀孕的第11—13天,在此期药物杀死胚胎后,胚胎仍留在子宫中被吸收,在胎仔死亡过程中,子宫有出血现象,个别的死胎在吸收过程中流出。第三阶段是在怀孕14天之后直至足月,各种流产剂的作用都导致活胎流产。这一止孕特点告诉我们在筛选计划生育药物时,若是为了观察药物杀死早期胚胎的效果,则应用怀孕10天之内的小白鼠;若是为了观察流产(排出)效果,则应用怀孕14天之后的小白鼠。而人的早期止孕是有排出特点的,所以用小白鼠筛选抗早孕药物时,既观察早期胚胎的杀死效果,同时也观察排出效果,这种筛选方法我们称谓“小白鼠比较止孕生理模型”筛选法。只有当观察到这两个指标的成功率都很高时,才可作进一步筛选。
In this experiment, we applied five kinds of different chemical agents, revealing the changes of the pregnancy status of the mice during pregnancy. This process of change does not change due to drug changes, but rather depends on the mouse’s own physiological characteristics of the pregnancy. Pregnancy of pregnant mice during pregnancy changes can be divided into three stages. In the first phase, about 10 days after the pregnancy, the embryo has no excretion and remains absorbed in the uterus after the drug has killed the embryo. The second stage is during the first 11-13 days of pregnancy, after the drug kills the embryo during this period, the embryo remains in the uterus and is absorbed. During the fetal death, the uterus has bleeding and individual stillbirths flow out during absorption . The third stage is after 14 days of pregnancy until full-term, the role of various abortion agents lead to abortion. This feature of pregnancy only tells us that in the screening of family planning drugs, if you want to observe the effect of drugs to kill early embryos, then the application of mice within 10 days of pregnancy, if it is in order to observe the effect of abortion (discharge), the application of 14 days of pregnancy After the mouse. The early pregnancy is the discharge characteristics of people, so the screening of anti-early pregnancy with mouse drugs, both to observe the killing effect of early embryos, but also to observe the discharge effect, this screening method we call “mice compared Zhiji physiology Model ”screening method. Only when it is observed that the success rates of these two indicators are high, can they be further screened.