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各类与遗传因素有关的疾病患者,在不同程度上存在有一些HLA抗原频率差异,可能与其发病有一定联系,用34种HLA抗原对45名复发性急性中耳炎(rAOM)患儿和健康对照组进行对比研究,发现仅有HLA-A_2和A_3两种抗原存在显著差异,-A_2在患儿中的出现频率为80％(对照组为55.9％),-A_3在患儿中频率为11.1％(对照组27.5％),提示rAOM的发生与HLA抗原频率有一定联系,有遗传影响,具有-A_2抗原的个体易患病的相对危险率为2.56,这一发现可解释rAOM在某些种族和家族成员中的易发生倾向。
To some extent, there are some differences in the frequency of HLA antigens in patients with various genetic diseases, which may be related to the pathogenesis of these diseases. Forty-five patients with relapsed acute otitis media (rAOM) and healthy controls A comparative study showed that only HLA-A 2 and A 3 antigens were found to be significantly different. The frequency of A-2 in children was 80% (control group, 55.9%). The frequency of A 3 in children was 11.1% 27.5% of the control group), suggesting that the occurrence of rAOM and HLA antigen frequency has a genetic relationship with the risk of individuals with-A2 antigen predisposing relative risk of 2.56, this finding may explain rAOM in some races and families Members prone to tendencies.