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通过体内与体外实验证明不同粉尘诱导肺冲洗细胞释放白细胞介素-1与其促成纤维细胞增殖活性水平相干行。不同粉尘诱导释放白细胞介素-1的能力与其所致肺纤维化作用之间也具有良好的相关性,提示白细胞介素-1很可能在肺组织纤维化的发展过程中起重要作用。
In vitro and in vivo experiments demonstrated that different dust induced interleukin-1 release in lung-irrigated cells correlated with the levels of fibroblast proliferation-promoting activity. There is also a good correlation between the ability of different dusts to induce the release of interleukin-1 and its role in pulmonary fibrosis, suggesting that interleukin-1 is likely to play an important role in the development of lung fibrosis.