目的观察由黄芪、白术、淫羊藿组成的复方制剂(壮骨肾宝)对实验性小鼠高脂血症的影响。方法用蛋黄乳液快速致小鼠单纯性高胆固醇血症和喂养高脂饲料致高脂血症模型 ,观察预防性给予不同剂量的壮骨肾宝后对血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL -ch)的影响。结果壮骨肾宝中、高剂量能使血清TC降低(P<0.05),HDL -ch升高(P<0.01) ,但对TG的影响不大。结论壮骨肾宝有一定降血脂作用 ,并与剂量有关 Objective To observe the effect of compound preparation (Zhuang Gu Shen Shen Bao) composed of Radix Astragali, Atractylodes macrocephala, and Epimedium on hyperlipidemia in experimental mice. Methods Hyperlipidemia was induced rapidly in mice with egg yolk emulsion and hyperlipidemia was induced in high fat diet. The serum total cholesterol (TC) and triglyceride levels were observed after different doses of Zhuanggu Shenbao were given prophylactically. TG) and high-density lipoprotein cholesterol (HDL-CH) effects. The results of Zhuanggu Shenbao high doses of serum TC can reduce (P <0.05), HDL-ch increase (P <0.01), but little effect on TG. Conclusion Zhuanggu Shenbao has certain hypolipidemic effect and related to dose