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了解和比较利福平等 6种抗菌药物对结核分枝杆菌的体外抗菌活性。采用琼脂稀释法测定了单药和不同组合药物对临床分离的 30株结核分枝杆菌的最低抑菌浓度 (MIC)。结果利福平 (RFP)、异烟肼(INH)、帕司烟肼 (PSN)、吡嗪酰胺 (PZA)、链霉素 (SM)、左氧氟沙星 (L VL X)的 MIC5 0 分别为 2 0、<0 .0 6、<0 .0 6、8、5、0 .5 ml/ L,不同组合药物的 MIC值比单药均下降 2～ 8倍。结论 :依照药敏试验结果 ,选择敏感的化疗方案 ,是处理耐药菌株病例的最佳对策。
To understand and compare the antibacterial activity of 6 kinds of rifampin in vitro to Mycobacterium tuberculosis in vitro. The minimum inhibitory concentration (MIC) of 30 strains of Mycobacterium tuberculosis clinically isolated by single drug and different combination drugs was determined by agar dilution method. Results The MIC50 of RFP, INH, PSN, PZA, SM and L VL X were 20 , <0.06, <0.06,8,5,0. 5 ml / L, the MIC value of different combinations of drugs decreased by 2 to 8 times than the single drug. Conclusion: According to the results of drug susceptibility test, the selection of sensitive chemotherapy regimens is the best way to deal with drug-resistant strains.