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目的:探讨干燥综合征合并神经系统损害的临床特点。方法:报道1例临床确诊为干燥综合征合并神经系统损害的患者,结合其头颅MRI、血清学免疫抗体检测结果,并复习文献,总结该类患者的临床特点。结果:约25%的干燥综合征患者合并出现神经系统受累症状,该类患者应与多发性硬化进行鉴别。头颅MRIFLAIR易发现干燥综合征合并神经系统损害患者的皮质下白质内的亚临床病灶。结论:临床中若发现患者的症状体征与颅内多发病灶不相符时,需行免疫相关抗体、腺体功能等方面的检测,考虑干燥综合征合并神经系统损害可能。
Objective: To investigate the clinical features of Sjogren’s syndrome combined with nervous system damage. Methods: One patient diagnosed as Sjogren’s syndrome with neurological damage was reported. Combined with the results of cranial MRI and serological antibody detection, the literature was reviewed and the clinical features of these patients were summarized. Results: About 25% of patients with Sjögren’s syndrome have symptoms of neurological involvement. Such patients should be differentiated from multiple sclerosis. Skull MRIFLAIR is prone to subclinical lesions within the subcortical white matter of patients with Sjogren’s syndrome and neurological compromise. Conclusion: If clinical symptoms and signs found in patients with multiple intracranial lesions do not meet the need for immune-related antibodies, gland function and other aspects of the test, consider the possibility of Sjogren’s syndrome complicated with nervous system damage.