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目的:对小儿热性惊厥复发的临床高危因素进行研究,为临床预防热性惊厥复发的发生提供可能的支持。方法:随机选取2002～2010年苏州大学附属儿童医院确诊为上呼吸道感染及热性惊厥复发患儿30例作为观察组,有上呼吸道感染及高热但未发生热性惊厥的患儿30例分为对照组,两组年龄及性别无统计学差异。观察两组患儿16个指标(如:性别、年龄、日托儿童等),再将阳性结果放入Logistic回归方程进行多因素分析。结果:发现观察组患儿中:日托儿童,一、二级亲属中热性惊厥史、围产期异常史、发育迟缓史、代谢性酸中毒、低血钠、低血锌、低钙、低血镁、缺铁性贫血、脑电图异常、头颅CT异常与对照组比较有统计学差异(P<0.05)。再将上述高危因素放入Logistic回归方程进行多因素分析,发现日托儿童,一、二级亲属中热性惊厥史、围产期异常史、低血钠、低血锌、缺铁性贫血与热性惊厥复发的发生有显著相关性。结论:日托儿童、家族史、围产期异常史、低血钠、低血锌,缺铁性贫血与热性惊厥复发有显著相关性,以上结论可进一步指导临床,预防热性惊厥复发的发生。
Objective: To study the clinical risk factors of relapse in children with febrile seizures, and to provide possible support for the clinical prevention of recurrence of febrile seizures. Methods: Thirty children with recurrent upper respiratory tract infection and febrile seizures were selected randomly from the Children’s Hospital Affiliated to Soochow University from 2002 to 2010. As the observation group, 30 children with upper respiratory tract infection and high fever but no febrile seizures The control group, no significant difference between the two groups of age and gender. Sixteen indicators (such as gender, age, day care child) of two groups were observed, then the positive results were put into Logistic regression equation for multivariate analysis. Results: In the observation group, there were no significant differences in the incidence of febrile seizures, abnormal perinatal history, history of developmental delay, metabolic acidosis, hyponatremia, hyponatremia, hypocalcemia, Hypoglycemia, iron deficiency anemia, EEG abnormalities, head CT abnormalities compared with the control group were statistically significant (P <0.05). Then the risk factors into the Logistic regression equation for multivariate analysis found that day care children, first and second relatives in febrile seizures, abnormal perinatal history, hyponatremia, low blood zinc, iron deficiency anemia and There was a significant correlation between the occurrence of recurrent febrile seizures. Conclusion: There is a significant correlation between children with detoxification, family history, abnormal perinatal history, hyponatremia, hyponatremia, iron deficiency anemia and recurrence of febrile seizures. These conclusions can further guide clinical and prevent the recurrence of febrile seizures occur.